李久全;

• 1:沈阳维康医院神经内科

摘要(Abstract)：

目的探讨盐酸替罗非班氯化钠注射液治疗卒中预警综合征的有效性及安全性。方法 2015-01—2018-03沈阳维康医院收治卒中预警综合征患者12例,给予盐酸替罗非班氯化钠注射液治疗。另收集2010-01—2014-12治疗的卒中预警综合征患者10例为对照组,给予阿司匹林及氯吡格雷双联抗血小板聚集治疗。观察2组患者用药后TIA样症状出现率、脑梗死转化率、出院时NIHSS评分、3个月后mRS评分及不良事件发生率。结果研究组TIA样症状出现率明显低于对照组(P<0.05),末次症状出现时间也明显少于对照组(P<0.05)。研究组进展为急性脑梗死的比率41.7%,对照组为90%,研究组明显低于对照组(P=0.031)。研究组出院时NIHSS评分(3.11±4.72)分,明显低于对照组的(7.93±5.21)分(P<0.05)。研究组患者3个月后mRS评分(0.64±1.99)分,明显优于对照组的(3.15±1.72)分。2组均未出现症状性颅内出血、其他部位出血及死亡患者。结论替罗非班能够有效控制卒中预警综合征患者的临床发作,显著缩短持续发作时间,能够有效减少演化为急性脑梗死的患者比率,改善卒中预警综合征患者神经功能缺损及远期临床预后,改善生活质量,安全性良好。

关键词(KeyWords)： 卒中预警综合征;替罗非班;阿司匹林;氯吡格雷;颅内出血;安全性

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 李久全;

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