同型半胱氨酸水平与脑梗死相关因素探讨
胡俊祥,杨东宁,樊润润
摘要(Abstract):
目的探讨同型半胱氨酸水平与脑梗死相关因素的关系。方法对78例脑梗死患者有无相关危险因素、是否进展和治疗前后的同型半胱氨酸进行统计分析。结果按照患者有无相关危险因素分组,2组同型半胱氨酸水平均无显著差异(P>0.05);按照进展与否、经叶酸和维生素B6治疗前后分组,2组同型半胱氨酸水平差异有统计学意义(P<0.05)。结论同型半胱氨酸水平与相关危险因素无关,与是否进展有关。
关键词(KeyWords): 脑梗死;进展型;同型半胱氨酸
基金项目(Foundation):
作者(Author): 胡俊祥,杨东宁,樊润润
参考文献(References):
- [1]Boushey CJ,Beresford SA,Omenn GS,et al.A quantitativeassessment of plasma homocysteine as a riskfactor for vasculardisease[J].JAMA,1995,274:1 049-1 057.
- [2]饶明俐.《中国脑血管病防治指南》摘要[J].中风与神经疾病杂志,2005,22(5):388-393.
- [3]Amytis Towfighi,MD.Factors associated with the steep in-crease in late midlife stroke occurrence among US men[J].Journal of stroke and cerebrovascular diseases,2008,17(4):165-168.
- [4]黄海威.1020名社区人群同型半胱氨酸水平的调查和相关分析[J].中华流行病学杂志,2006,27(8):23-25.
- [5]Kristensen B,Mal m J,Nilsson TK,et al.Hyperhomocysteinemia and hypofibrinolysis in young adults with ischemicstroke[J].Stroke,1999,30(5):974-980.
- [6]EI Kossi MMH,Zakhay MM.Oxidative stress in the contextof acute cerebrovascular stroke[J].Stroke,2000,31(8):1 889-1 892.
- [7]Penix LP.Ischemic stroke secondary to vitamin B12 deficiency-induced hyperhomocysteinemia[J].Neurology,1998,51:622-624.
- [8]马丽丽.急性脑梗死患者血清同型半胱氨酸水平及治疗探讨[J].中国实用神经疾病杂志,2009,12(24):49-50.