孙慧勤;宋璞;赵莉;陈巍巍;孙卫红;师毅冰;李晨旭;白胜杰;

• 1:徐州市中心医院

摘要(Abstract)：

帕金森病的诊断和病情分析主要依赖于症状和体征，而无创无辐射的辅助检查较少，传统的磁共振扫描不能发现帕金森病异常。近年来基于扩散原理成像的磁共振技术应用越来越广泛，其中磁共振扩散峰度成像因其原理建立在非高斯分布基础上，较弥散张量成像更贴合人体真实情况，能早期、精准量化帕金森病脑组织微观结构的异常，故本文对帕金森病的扩散峰度成像研究进展进行综述。

关键词(KeyWords)： 帕金森病;扩散峰度成像;磁共振成像;神经系统变性疾病;运动症状;非运动症状;动物模型

Abstract:

Keywords:

基金项目(Foundation): 徐州市科技局重点研发项目（编号：KC19177）

作者(Authors): 孙慧勤;宋璞;赵莉;陈巍巍;孙卫红;师毅冰;李晨旭;白胜杰;

参考文献(References)：

• [1]DORSEY E R,SHERER T,OKUN M S,et al.The Emerging Evidence of the Parkinson Pandemic[J].J Parkinsons Dis,2018,8(s1):S3-3S8.DOI:10.3233/JPD-181474.
• [2]DAS S K,WANG J L,BING L,et al.Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain during Normal Aging[J].Clin Neuroradiol,2017,27(3):283-298.DOI:10.1007/s00062-015-0490-z.
• [3]HANSEN B.An Introduction to Kurtosis Fractional Anisotropy[J].AJNR Am J Neuroradiol,2019,40(10):1638-1641.DOI:10.3174/ajnr.A6235.
• [4]ARAB A,WOJNA-PELCZAR A,KHAIRNAR A,et al.Principles of diffusion kurtosis imaging and its role in early diagnosis of neurodegenerative disorders[J].Brain Res Bull,2018,139:91-98.DOI:10.1016/j.brainresbull.2018.01.015.
• [5]RIZEK P,KUMAR N,JOG M S.An update on the diagnosis and treatment of Parkinson disease[J].CMAJ,2016,188(16):1157-1165.DOI:10.1503/cmaj.151179.
• [6]KHAIRNAR A,LATTA P,DRAZANOVA E,et al.Diffusion Kurtosis Imaging Detects Microstructural Alterations in Brain ofα-Synuclein Overexpressing Transgenic Mouse Model of Parkinson’s Disease:A Pilot Study[J].Neurotox Res,2015,28(4):281-289.DOI:10.1007/s12640-015-9537-9.
• [7]KHAIRNAR A,RUDA-KUCEROVA J,DRAZANOVA E,et al.Late-stage α-synuclein accumulation in TNWT-61 mouse model of Parkinson’s disease detected by diffusion kurtosis imaging[J].JNeurochem,2016,136(6):1259-1269.DOI:10.1111/jnc.13500.
• [8]ARAB A,RUDA-KUCEROVA J,MINSTEROVA A,et al.Diffusion Kurtosis Imaging Detects Microstructural Changes in a Methamphetamine-Induced Mouse Model of Parkinson’s Disease[J].Neurotox Res,2019,36(4):724-735.DOI:10.1007/s12640-019-00068-0.
• [9]KHAIRNAR A,RUDA-KUCEROVA J,ARAB A,et al.Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson’s disease[J].J Neurochem,2021,158(3):779-797.DOI:10.1111/jnc.15449.
• [10]ZHANG G,ZHANG Y,ZHANG C,et al.Diffusion Kurtosis Imaging of Substantia Nigra Is a Sensitive Method for Early Diagnosis and Disease Evaluation in Parkinson’s Disease[J].Parkinsons Dis,2015,2015:207624.DOI:10.1155/2015/207624.
• [11]GUAN J,MA X,GENG Y,et al.Diffusion Kurtosis Imaging for Detection of Early Brain Changes in Parkinson’s Disease[J].Front Neurol,2019,10:1285.DOI:10.3389/fneur.2019.01285.
• [12]GUGLIELMETTI C,VERAART J,ROELANT E,et al.Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone induced demyelination and spontaneous remyelination[J].Neuroimage,2016,125:363-377.DOI:10.1016/j.neuroimage.2015.10.052.
• [13]BRAECKMAN K,DESCAMPS B,PIETERS L,et al.Dynamic changes in hippocampal diffusion and kurtosis metrics following experimental m TBI correlate with glial reactivity[J].Neuroimage Clin,2019,21:101669.DOI:10.1016/j.nicl.2019.101669.
• [14]BINGBING G,YUJING Z,YANWEI M,et al.Diffusion Kurtosis Imaging of Microstructural Changes in Gray Matter Nucleus in Parkinson Disease[J].Front Neurol,2020,11:252.DOI:10.3389/fneur.2020.00252.
• [15]陈婧，钟侦，张君君，等.帕金森病伴快速眼动睡眠行为障碍的弥散张量成像研究[J].中国实用神经疾病杂志，2022,25(2):139-144.DOI:10.12083/SYSJ.211628.
• [16]FAN Z,AMAN Y,AHMED I,et al.Influence of microglial activation on neuronal function in Alzheimer’s and Parkinson’s disease dementia[J].Alzheimers Dement,2015,11 (6):608.e7-621.e7.DOI:10.1016/j.jalz.2014.06.016.
• [17]ZHANG G,ZHANG C,WANG Y,et al.Is hyperhomocysteinemia associated with the structural changes of the substantia nigra in Parkinson’s disease?A two-year follow-up study[J].Parkinsonism Relat Disord,2019,60:46-50.DOI:10.1016/j.parkreldis.2018.10.008.
• [18]ZHANG G,ZHANG C,ZHANG Y,et al.The effects of striatal silent lacunar infarction on the substantia nigra and movement disorders in Parkinson’s disease:A follow-up study[J].Parkinsonism Relat Disord,2017,43:33-37.DOI:10.1016/j.parkreldis.2017.06.020.
• [19]SUROVA Y,LAMPINEN B,NILSSON M,et al.Alterations of Diffusion Kurtosis and Neurite Density Measures in Deep Grey Matter and White Matter in Parkinson’s Disease[J].PLo S One,2016,11(6):e0157755.DOI:10.1371/journal.pone.0157755.
• [20]SUROVA Y,NILSSON M,LAMPINEN B,et al.Alteration of putaminal fractional anisotropy in Parkinson’s disease:a longitudinal diffusion kurtosis imaging study[J].Neuroradiology,2018,60 (3):247-254.DOI:10.1007/s00234-017-1971-3.
• [21]KAMAGATA K,TOMIYAMA H,MOTOI Y,et al.Diffusional kurtosis imaging of cingulate fibers in Parkinson disease:comparison with conventional diffusion tensor imaging[J].Magn Reson Imaging,2013,31(9):1501-1506.DOI:10.1016/j.mri.2013.06.009.
• [22]KAMAGATA K,TOMIYAMA H,HATANO T,et al.A preliminary diffusional kurtosis imaging study of Parkinson disease:comparison with conventional diffusion tensor imaging[J].Neuroradiology,2014,56(3):251-258.DOI:10.1007/s00234-014-1327-1.
• [23]ATKINSON-CLEMENT C,PINTO S,EUSEBIO A,et al.Diffusion tensor imaging in Parkinson’s disease:Review and meta-analysis[J].Neuroimage Clin,2017,16:98-110.DOI:10.1016/j.nicl.2017.07.011.
• [24]SCHEKEB A,ANDREAS S L.MRI Signs of Parkinson’s Disease and Atypical Parkinsonism[J].Rofo,2021,193(12):1403-1410.DOI:10.1055/a-1460-8795.
• [25]KAMAGATA K,ZALESKY A,HATANO T,et al.Gray Matter Abnormalities in Idiopathic Parkinson’s Disease:Evaluation by Diffusional Kurtosis Imaging and Neurite Orientation Dispersion and Density Imaging[J].Hum Brain Mapp,2017,38(7):3704-3722.DOI:10.1002/hbm.23628.
• [26]BAI X,ZHOU C,GUO T,et al.Progressive microstructural alterations in subcortical nuclei in Parkinson’s disease:Adiffusion magnetic resonance imaging study[J].Parkinsonism Relat Disord,2021,88:82-89.DOI:10.1016/j.parkreldis.2021.06.003.
• [27]TAYLOR K I,SAMBATARO F,BOESS F,et al.Progressive Decline in Gray and White Matter Integrity in de novo Parkinson’s Disease:An Analysis of Longitudinal Parkinson Progression Markers Initiative Diffusion Tensor Imaging Data[J].Front Aging Neurosci,2018,10:318.DOI:10.3389/fnagi.2018.00318.
• [28]MONJE M,BLESA J,GARCíA-CABEZAS Má，et al.Changes in thalamic dopamine innervation in a progressive Parkinson’s disease model in monkeys[J].Mov Disord,2020,35(3):419-430.DOI:10.1002/mds.27921.
• [29]SEJNOHA MINSTEROVA A,KLOBUSIAKOVA P,PIES A,et al.Patterns of diffusion kurtosis changes in Parkinson’s disease subtypes[J].Parkinsonism Relat Disord,2020,81:96-102.DOI:10.1016/j.parkreldis.2020.10.032.
• [30]刘依然，刘泰松，宋金辉.帕金森病不同运动亚型白质纤维损害的弥散张量成像研究[J].中国实用神经疾病杂志，2022,25(3):300-305.DOI:10.12083/SYSJ.211769.
• [31]ITO K,SASAKI M,OHTSUKA C,et al.Differentiation among parkinsonisms using quantitative diffusion kurtosis imaging[J].Neuroreport,2015,26 (5):267-272.DOI:10.1097/WNR.0000000000000341.
• [32]BERGAMINO M,KEELING E G,MISHRA V R,et al.Assessing White Matter Pathology in Early-Stage Parkinson Disease Using Diffusion MRI:A Systematic Review[J].Front Neurol,2020,11:314.DOI:10.3389/fneur.2020.00314.
• [33]GONG N J,WONG C S,CHAN C C,et al.Correlations between microstructural alterations and severity of cognitive deficiency in Alzheimer’s disease and mild cognitive impairment:a diffusional kurtosis imaging study[J].Magn Reson Imaging,2013,31(5):688-694.DOI:10.1016/j.mri.2012.10.027.
• [34]ASSAF Y,PASTERNAK O.Diffusion tensor imaging(DTI)-based white matter mapping in brain research:a review[J].J Mol Neurosci,2008,34 (1):51-61.DOI:10.1007/s12031-007-0029-0.
• [35]HOULDEN H,SINGLETON A B.The genetics and neuropathology of Parkinson’s disease[J].Acta Neuropathol,2012,124(3):325-338.DOI:10.1007/s00401-012-1013-5.
• [36]张辉,王运良.帕金森病的发病机制及治疗进展[J].中国实用神经疾病杂志，2021,24(15):1371-1380.
• [37]TAN S,HARTONO S,WELTON T,et al.Utility of quantitative susceptibility mapping and diffusion kurtosis imaging in the diagnosis of early Parkinson’s disease[J].Neuroimage Clin,2021,32:102831.DOI:10.1016/j.nicl.2021.102831.
• [38]HANSEN B.Diffusion Kurtosis Imaging as a Tool in Neurotoxicology[J].Neurotox Res,2020,37(1):41-47.DOI:10.1007/s12640-019-00100-3.
• [39]YANG L,CHENG Y,SUN Y,et al.Combined Application of Quantitative Susceptibility Mapping and Diffusion Kurtosis Imaging Techniques to Investigate the Effect of Iron Deposition on Microstructural Changes in the Brain in Parkinson’s Disease[J].Front Aging Neurosci,2022,14:792778.DOI:10.3389/fnagi.2022.792778.
• [40]KAMAGATA K,ANDICA C,HATANO T,et al.Advanced diffusion magnetic resonance imaging in patients with Alzheimer’s and Parkinson’s diseases[J].Neural Regen Res,2020,15(9):1590-1600.DOI:10.4103/1673-5374.276326.
• [41]KHAIRNAR A,RUDA-KUCEROVA J,ARAB A,et al.Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson’s disease[J].J Neurochem,2021,158(3):779-797.DOI:10.1111/jnc.15449.