MMP-2、MMP-9基因多态性与缺血性脑卒中临床分型及预后Study on polymorphisms of matrix metalloproteinase-2 and-9 genes,and clinical classification and prognosis of ischemic stroke
刘丹,王亚春,孙洪英,连瑜,贾璐,吴丽娥,王贵喜,郭霞
摘要(Abstract)：
目的探讨基质金属蛋白酶2(Matrix Metalloproteinase-2,MMP-2)基因C1306T、C735T和MMP-9基因C1562T多态性位点与缺血性脑卒中的关系。方法采用限制性片段长度多态性分析技术,检测缺血性脑卒中组232例和健康对照组235例MMP-2基因C1306T、C735T和MMP-9基因C1562T多态的分布。结果缺血性脑卒中组和对照组MMP-2 C1306T基因型和等位基因频率分布无统计学意义。在动脉粥样硬化性血栓性脑梗死组MMP-9 C1562T的CT+TT基因型频率和T等位基因频率、MMP-2 C735T的CC基因型频率和C等位基因频率明显高于对照组(P<0.05),而在脑栓塞组、腔梗组差异无统计学意义(P>0.05)。多因素Logistic回归分析,MMP-2、MMP-9不同基因型别与缺血性脑卒中预后无显著相关性(P>0.05)。结论 MMP-2 C735T的C等位基因、MMP-9 C1562T的T等位基因是动脉粥样硬化性血栓性脑梗死的遗传易感基因之一。MMP-2、MMP-9基因多态性与缺血性脑卒中预后无关。
关键词(KeyWords)： 基质金属蛋白酶-2、9基因多态性;缺血性脑卒中;临床分型;预后
基金项目(Foundation):
作者(Author): 刘丹,王亚春,孙洪英,连瑜,贾璐,吴丽娥,王贵喜,郭霞
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