5-羟色胺转运体基因多态性与脑卒中后抑郁的关系Association between polymorphisms of 5-HT transporter gene and post-stroke depression
曹金霞,耿德勤,姜建东,刘莉,姜玉龙,孙德锦
摘要(Abstract)：
目的探讨5-羟色胺转运体基因启动子区域多态性(5-HTTLPR)与中国汉族人群脑卒中后抑郁(PSD)的关系。方法应用PCR技术,比较96例PSD、97例脑卒中后非PSD及60名健康对照组上述位点基因型及等位基因频率。结果 PSD组5-HTTLPR多态的S/S基因型频率和S等位基因频率显著高于脑卒中非PSD组和健康对照组(均P<0.05),S等位基因与PSD呈正关联(比值比OR=1.76,P<0.01,95%CI:1.15～2.69)。结论 5-HTTLPR S/S基因型和S等位基因可能为脑卒中后抑郁的易患因素。
关键词(KeyWords)： 5-羟色胺转运体;脑卒中后抑郁;基因多态性
基金项目(Foundation):
作者(Author): 曹金霞,耿德勤,姜建东,刘莉,姜玉龙,孙德锦
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