季玉陈,牛光明,张鹏远,娄金锋,周兴,常克亮,陶胜忠,苏芳忠

• 1:郑州大学第二附属医院神经外科

摘要(Abstract)：

目的探讨PTTG、MMP-2在人脑星形细胞瘤中的表达,研究其与病理分级的关系,分析二者在表达过程中的相互关系。方法采用免疫组织化学S-P法检测PTTG、MMP-2在正常脑组织及在不同病理级别人脑星形细胞瘤中的表达。结果 PTTG、MMP-2在2组阳性表达比较差异有统计学意义(P<0.05),表达阳性率随病理级别的增高呈增高趋势,低度恶性组与恶性组比较差异有统计学意义(P<0.05),而恶性组与高度恶性组比较差异无统计学意义(P>0.05),二者在表达过程中存在正相关(r=0.504,P<0.05)。结论 PTTG和MMP-2在人脑星形细胞瘤的发生发展过程中存在正相关性,PTTG可能通过MMP-2促进肿瘤的发生和发展。

关键词(KeyWords)： 星形细胞瘤;PTTG;MMP-2;免疫组织化学

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 季玉陈,牛光明,张鹏远,娄金锋,周兴,常克亮,陶胜忠,苏芳忠

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