屈新辉,王卫真,蒋婷,何丹,谢旭芳,吴晓牧,张昆南

• 1:江西省人民医院神经内科
• 2:江西省人民医院超声诊断科
• 3:江西省人民医院中心实验室

摘要(Abstract)：

目的探讨缺血性脑血管病患者颈动脉粥样硬化程度与循环内皮祖细胞(EPCs)的相关性。方法根据CD133和KDR标记,采用流式细胞仪检测缺血性脑血管病患者(包括TIA、急性脑梗死、颈动脉粥样硬化)和健康体检者外周血内皮祖细胞(EPCs)数量变化。结果缺血性脑血管病患者EPCs数量较对照组明显减少(P<0.01);随着颈动脉粥样硬化程度加重,EPCs数量呈降低趋势,颈动脉重度狭窄与轻度和中度狭窄相比有差异(P<0.05);急性脑梗死和TIA患者较单纯颈动脉粥样硬化患者EPCs数量明显增加(P<0.01)。结论缺血性脑血管病患者EPCs与颈动脉粥样硬化程度呈负相关,可反映颈动脉粥样硬化的程度;急性缺血可能会增加EPCs的动员。

关键词(KeyWords)： 缺血性脑血管病;脑梗死;TIA;颈动脉粥样硬化;颈动脉狭窄;内皮祖细胞(EPCs)

Abstract:

Keywords:

基金项目(Foundation): 十一五国家科技支撑计划资助项目(2008BAI68B03)

作者(Author): 屈新辉,王卫真,蒋婷,何丹,谢旭芳,吴晓牧,张昆南

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