刘丹,王亚春,杨静,张广炜,杨玉蓉,张伟,王甫,崔丽丽,李秀娟,刘秀云

• 1:包头医学院第一附属医院神经内科

摘要(Abstract)：

目的探讨连接蛋白37(connexins37,CX37)基因I1297D多态性位点与缺血性脑卒中及其亚型的关系。方法采用限制性片段长度多态性分析技术,检测缺血性脑卒中组232例(根据诊断分为动脉粥样硬化性血栓性脑梗死组115例,脑栓塞组31例,腔隙性脑梗死组86例)和健康对照组235例CX37基因I1297D多态的分布。结果 CX37基因I1297D多态性,缺血性脑卒中组和对照组中均以II基因型和I等位基因为主。基因型(II型I、D型、DD型)I、和D等位基因分布频率在缺血性脑卒中组分别为46.56%、39.22%、14.22%、66.16%和33.84%,对照组分别为47.66%、43.40%、8.94%、69.36%和30.64%,2组比较差异无统计学意义(P>0.05),且其基因型、等位基因分布频率在缺血性脑卒中各亚型之间与对照组比较,差异无统计学意义(P>0.05)。结论 CX37基因I1297D的多态性与缺血性脑卒中易感性无关。

关键词(KeyWords)： 连接蛋白37基因多态性;缺血性脑卒中;临床分型

Abstract:

Keywords:

基金项目(Foundation): 内蒙古教育厅项目(NJ10188)

作者(Author): 刘丹,王亚春,杨静,张广炜,杨玉蓉,张伟,王甫,崔丽丽,李秀娟,刘秀云

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