缺氧后肌阵挛2例报道并文献复习Posthypoxic myoclonus:Report of 2 cases and review of literature
吴志生,于凯
摘要(Abstract)：
目的探讨缺氧后肌阵挛(posthypoxic myoclonus,PHM)的发病机制、临床表现、神经电生理、治疗及预后。方法收集2例PHM患者临床资料,分析其临床表现、脑电图特征及治疗及预后,并复习文献。结果 2例患者为心肺复苏后病人,表现反复发作短暂而快速的肢体抽动,脑电图显示无癫活动,常规抗癫治疗效果不肯定。结论 PHM临床表现与肌阵挛癫相似,电生理检查无特异性,拉莫三嗪、左乙拉西坦等药物可试用于临床。
关键词(KeyWords)： 缺氧后肌阵挛;发病机制;药物治疗
基金项目(Foundation):
作者(Author): 吴志生,于凯
参考文献(References)：
- [1]Lance JW,Adams RD.The syndrome of intention or action my-oclonus as a sequel to hypoxic encephalopathy[J].Brain,1963,86:111-136.
- [2]Frucht SJ,Trost M,Ma Y,et al.The metabolic topography ofposthypoxic myoclonus[J].Neurology,2004,62:1 879-1 881.
- [3]Zivkovic SA,Brennet RP.A case of area-specfic stimulus-sensi-tive postanoxic myoclonus[J].J Clin Neurophysiology,2003,20:111-116.
- [4]Pappert EJ,Goetz CG,Vu TQ,et al.Anmial models of posthy-poxic myoclonus:effects of serotoninergic antagonists[J].Neu-rology,1999,52:16-21.
- [5]Kanthasamy AG,Nguyen Bang,Truong DD.Role of serotoner-gic neurotransmission in the pathophypoxic myoclonus[J].Neurology,1998,50:A135-A136.
- [6]Gimenez-Roldan S,Mateo D,Muradas V,et al.Clinical,bio-chemical,and pharmacological observation in a patient withpostasphyxic myoclonus:association to serotonin hyperactivity[J].Clin Neurophamacol,1988,11:151-160.
- [7]Kompoliti K,Goetz,CG,Vu TQ,et al.Estrogen supplementa-tion in the posthypoxic myoclonus rat model[J].Clin Neurop-harmacol,2001,24:58-61.
- [8]魏春风,黄希顺,刘伟.拉莫三嗪治疗各型癫的疗效分析[J].中国实用神经疾病杂志,2009,12(11):60-62.
- [9]Kanthasamy AG,Tith T,Nguyen B,et al.Antimyoclonic andneuroprotective effects of lamotrigine in an animal model ofcardiac arrest[J].Restor Neurosci,1999,15:45-56.
- [10]Cheramy A,Barbeito L,Godeheu G,et al.Riluzole inhibits therelease of glutamate in the caudate nucleus of the cat in vivo[J].Neurosci Lett,1992,147:209-212.
- [11]Krauss GL,Bergin A,Kramer RE,et al.Suppression of post-encephalitic myoclonus with levetiracetam[J].Neurology,2001,56:411-412.
- [12]Werhahn KJ,Brown P,Thompson PD,et al.The clinical fea-tures and prognosis of chronic posthypoxic myoclonus[J].Mov Disord,1997,12:216-220.