恶性滋养细胞肿瘤脑转移的临床特点与疗效分析
赵虎,黄冬梅,王武亮,张庆,邓克红
摘要(Abstract)：
目的探讨恶性滋养细胞肿瘤脑转移的临床特点、治疗方法和疗效。方法回顾性分析629例恶性滋养细胞肿瘤中发生脑转移的49例患者的临床资料。结果脑转移发生率7.79%,39例患者经正规化疗后缓解率84.62%,发生脑转移时未曾化疗、曾行化疗和耐药患者的缓解率分别为80.95%、72.73%和0。结论恶性滋养细胞肿瘤脑转移预后极差,早期诊断与及时正规的化疗是改善预后的关键。
关键词(KeyWords)： 滋养细胞肿瘤;脑转移;化学治疗
基金项目(Foundation):
作者(Author): 赵虎,黄冬梅,王武亮,张庆,邓克红
参考文献(References)：
- [1]Behtash N,Behnamfar F,Hamedi B,et al.Term delivery fol-lowing successful treatment of choriocarcinoma with brain me-tastases,a case report and review of literature[J].Arch Gyne-col Obstet,2009,279(4):579-581.
- [2]Crawford RF,Newlands ES,Rustin GJS,et al.Gestationaltrophoblastic disease with liver metastases:the Charing Crossexperience[J].Br J Obstet Gynecol,1997,104:105-109.
- [3]黄冬梅,王武亮,郑英,等.35例恶性滋养细胞肿瘤脑转移的临床转归[J].实用妇产科杂志,2005,21(5):290-292.
- [4]Jones WB,Cardinale C,Lewis JH.Management of high-riskgestational trophoblastic disease.The memorial hospital expe-rience[J].Int J Gynecol Cancer,1997,7:27-33.