含铂方案联合脑放射治疗非小细胞肺癌脑转移的疗效评价
程传耀,周文鹏,胡宁
摘要(Abstract):
目的评价Topotecan联合顺铂方案与脑部放疗治疗非小细胞肺癌脑转移的临床近期疗效。方法对49例非小细胞肺癌伴脑转移患者采用Topotecan联合顺铂方案与脑部放疗进行序贯化放疗。结果联合顺铂方案与序贯脑部放疗治疗组中,神经功能障碍改善70.6%,脑部病灶客观有效率65.3%,肺部病灶的有效率为55.1%,两者比较差异有统计学意义(P<0.05)。结论 Topotecan联合顺铂方案与脑部放疗治疗非小细胞肺癌脑转移是一种有效的治疗非小细胞肺癌脑转移的治疗方案。
关键词(KeyWords): 化疗;非小细胞肺癌;脑转移;脑部放疗
基金项目(Foundation):
作者(Author): 程传耀,周文鹏,胡宁
参考文献(References):
- [1]陈龙邦,刘福坤.询证肿瘤学[M].郑州:郑州大学出版社,2004:636.
- [2]Quantin X,Khial F,Reme-Saumon M,et al.Concomitant brainradiotherapy.and vinorelbine-ifosfamide-cisplatin chemotherapyin brain meta stases of on-small cell lung cancer[J].LungCancer,1999,26(1):35-39.
- [3]Guerrieri M,Wong K,Ryan G,et al.A randomised phaseⅢstudy of palliativeradiation with concomitant carboplatin forbrain metastases from nonsmallcell carcinoma of the lung[J].Lung Cancer,2004,46(1):107-111.
- [4]Robinet G,Thomas P,Breton JL,et al.Results of a phaseⅢstudy of earlyversus delayed whole brain radiotherapy withconcurrent cisplatin vinorelbinecombination in inoperable brainmetastasis of non-small-cell lung cancer:Groupe Francais dePneumo-Cancerologie(GFPC)Protocol 95-1[J].Ann Oncol,2001,12(1):59-67.
- [5]Kim JH,Kim HS,Kwon JH,et al.Systemic chemotherapy af-ter cranial irradiationin patients with brain metastases fromnon-small cell lung cancer:aretrospective study[J].LungCancer,2009,63(3):405-409.
- [6]Lee DH,Han JY,Kim HT,et al.Primary chemotherapy fornewly diagnosed non small cell lung cancer patients with syn-chronous brain metastases comparedwith whole-brain radio-therapy administered first:result of a randomized pilot study[J].Cancer,2008,113(1):143-149.
- [7]Gizawy EL,Hedaya MA.Comparat ive brain tissue dist ribution of camptothecin and t opotecan in the rat[J].Ca ncer Che-mother Phar macol,1999,43(5):364-370.
- [8]Baker SD,H eid em an RL,C rom WR,et al.Cerebrosp inalfluid pharmacok inetics and penetration of continuous in fusiontopotecan in children with central nervous system tumers[J].Cancer Chemother Pharmaco,1996,37(3):195-202.
- [9]周际昌.实用肿瘤内科学[M].第2版.北京:人民卫生出版社,2003:45-47;29-30;340-341.