李云

• 1:大理学院附属医院神经内科

摘要(Abstract)：

目的研究脑卒中患者神经功能缺损程度与血清BDNF蛋白含量的相关性。方法选择住院确诊为脑卒中的患者45例,男27例,女18例,年龄34～82岁,平均58.76岁,其中脑梗死26例,脑出血19例;采用改良爱丁堡+斯堪的纳维亚脑卒中量表对患者进行神经功能缺损评分,并于住院次日采用酶联免疫吸附实验(ELISA)测定患者血清BDNF蛋白含量。结果本组患者中轻度神经功能缺损27例(60%);中度神经功能缺损者10例(22.2%);重度神经功能缺损者8例(17.8%)。直线相关分析发现,脑卒中患者神经功能缺损总体评分与血清BDNF蛋白含量之间存在直线相关关系,Person相关系数为-0.527,P<0.01。但不同程度神经功能缺损组中神经功能缺损分值与血清BDNF之间均无相关性(P>0.05)。结论神经功能缺损程度与脑卒中患者血清BDNF蛋白含量之间存在负性相关关系,脑卒中后血清BDNF蛋白含量可能是脑卒中严重程度的预测指标之一。

关键词(KeyWords)： 脑卒中;神经功能缺损;BDNF

Abstract:

Keywords:

基金项目(Foundation): 云南省教育厅基金资助项目

作者(Author): 李云

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