王龙海;黄志强;

• 1:达州市中西医结合医院

摘要(Abstract)：

目的 探讨脑小血管病所致血管性认知功能障碍（VCI）患者血管内皮生长因子（VEGF）、超敏C反应蛋白（hs-CRP）水平及脑血流灌注的临床意义。方法 选取达州市中西医结合医院2018-01—2021-03收治的125例脑小血管病患者，分为认知障碍患者79例（A组）和认知正常患者46例（B组），选取无脑小血管病史的健康志愿者30例为C组。比较VEGF、hs-CRP、脑血流灌注、MMSE评分、MoCA评分。分析脑小血管病认知功能与各指标的相关性。结果 A组的MMSE评分（22.71±3.02）分、MoCA评分（21.33±2.36）分、血清VEGF水平（166.28±33.57）ng/L、脑血流速度（CBFV）(88.63±15.49)cm/s、脑血流量（CBF）(673.42±50.33)m L/s，低于B组（27.82±0.63）分、（25.45±1.86）分、（194.60±38.12）ng/L、（95.22±17.63）cm/s、（733.68±58.11）m L/s,C组（28.05±0.56）分、（26.03±1.52）分、（216.53±42.30）ng/L、（101.66±20.41）cm/s、（759.12±64.08）mL/s(P<0.05),A组的血清hs-CRP水平（3.52±1.12）mg/L高于B组（2.87±0.95）mg/L、C组（2.05±0.41）mg/L(P<0.05)。MMSE评分、MoCA评分与VEGF、CBFV、CBF呈正相关（r=0.571,r=0.422,r=0.439,r=0.410,r=0.378,r=0.355），与hs-CRP呈负相关（r=—0.173,r=—0.256）。结论 血清VEGF低水平、hs-CRP高水平、脑血流低灌注与脑小血管病所致VCI密切相关，可能是导致VCI的机制。

关键词(KeyWords)： 脑小血管病;血管性认知功能障碍;血管内皮生长因子;超敏C反应蛋白;脑血流灌注

Abstract:

Keywords:

基金项目(Foundation): 达州市卫计委科研课题（编号：2018010）

作者(Authors): 王龙海;黄志强;

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