血清尿酸对颈部动脉病变严重程度的预示作用探讨
赵志中
摘要(Abstract)：
目的探讨血清尿酸水平与颈部动脉病变严重程度的关系。方法回顾分析187例住院行颈部动脉影像学检查患者的一般资料、生化检查等资料,分析血清尿酸与颈部动脉病变程度的相关关系。结果 187例患者中高尿酸血症的患病率51.34%,与非高尿酸组相比,高尿酸组患者BMI及LDL-C患病率高于非高尿酸组;根据尿酸分组后发现高尿酸组颈动脉病变患病率显著高于非高尿素组(87.50%vs 68.13%,2χ=10.237,P=0.001),差异具有统计学意义,与非高尿酸组相比,高尿酸组双支病变和多支病变的患病率均较对照组升高,分别为39.58%vs 25.27%(χ2=4.352,P=0.037)、33.33%vs15.38%(χ2=8.114,P=0.004)。结论血清尿酸浓度是预示颈部动脉病变严重程度的一个重要指标,在临床工作中应通过采取积极有效的措施控制高尿酸血症,以改善颈部动脉病变患者的预后。
关键词(KeyWords)： 血清尿酸;颈部动脉病;预示
基金项目(Foundation):
作者(Author): 赵志中
参考文献(References)：
- [1]Wdowczyk M,Bednarska-Chabowska D,Adamiec R.Role ofuric acid in cardiovascular diseases[J].Przegl Lek,2003,60(11):755-757.
- [2]Chen JH,Chuang SY,Chen HJ,et al.Serum uric acid level asan independent risk factor for all-cause,cardiovascular,and is-chemic stroke mortality:a Chinese cohort study[J].ArthritisRheum,2009,61(2):225-232.
- [3]Meisinger C,Koenig W,Baumert J,et al.Uric acid levels areassociated with all cause and cardiovascular disease mortalityindependent of systemic inflammation in men from the generalpopulation:The MONICAF/KORA Cohort Study[J].Arteri-oseler Thromb Vasc Bio,2008,28(6):1 186-1 192.
- [4]Holme l,Aastveit AH,Hammar N,et al.Uric acid and risk ofmyoeardial infarction,stroke and congestive heart failure in417734 men and women in the Apolipoprotein Mortality Riskstudy(AMORIS)[J].J Intern Med,2009,266(6):558-570.
- [5]Okura T,Higaki J,Kurata M,et al.Elevated serum uric acidis an independent predictor for cardiovascular events in patientswith severe coronary.artery stenosis:subanalysis of the Japa-nese Coronary Artery.Disease(JCAD)Study[J].Circ J,2009,73(5):885-891.