关春红,马致远,陈国光

• 1:广东医学院第二附属医院神经内科

摘要(Abstract)：

目的探讨2型糖尿病(DM)合并急性脑梗死(ACI)患者检测高敏C反应蛋白(hs-CRP)、脂蛋白a[Lp(a)]的临床价值。方法收集42例2型糖尿病合并急性脑梗死病例(DM+ACI组),40例单纯T2DM(DM组)及同期40例健康体检者(正常对照组),测定3组人群的hs-CRP、Lp(a)及其他生化指标,并对结果进行统计学分析。结果 DM+ACI组及DM组的血清hs-CRP、Lp(a)水平均显著高于正常对照组(P<0.05)。DM+ACI组血清Lp(a)显著高于DM组(P<0.05),2组hs-CRP水平比较差异无统计学意义(P>0.10)。结论 hs-CRP、Lp(a)检测对2型糖尿病并发急性脑梗死的风险度具有一定的预测价值。

关键词(KeyWords)： 超敏C反应蛋白;脂蛋白a;2型糖尿病;急性脑梗死

Abstract:

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基金项目(Foundation):

作者(Author): 关春红,马致远,陈国光

参考文献(References)：

• [1]Shin JY,Lee HR,Lee DC.Increased arterial stiffnessin healthysubjects with high-normal glucose levels and in subjects withpre-diabetes[J].Cardiovasc Diabetol,2011,10(1):30.
• [2]Ormstad H,Aass HC,Lund-Srensen N,et al.Serumlevels ofcytokines and C-reactive protein in acute ischemic stroke pa-tients,and their relationshipto stroke lateralization,type,andinfarct volume[J].J Neurol,2011,258(4):677-685.
• [3]Verma S,Kuliszewski MA,Li SH,et al.C-reactive protein at-tenuate endothelial progenitor cell survival differentiation,andfunction:further evidence of a mechanistic link between C-re-active protein and cardiovascular disease[J].Circulation,2004,109:2 058-2 067.
• [4]Laaksonen DE,Niskanen L,Nyyssnen K,et al.C-reactiveprotein and the development of the metabolic syndrome and di-abetesin middle-aged men[J].Diabetologia,2004,47:1 403-1410.
• [5]Yokokawa H,Yasumura S,Tanno K,et al.Serumlow-densi-ty lipoprotein to high-density lipoprotein ratio as a predictor offuture acute myocardial infarction among menin a 2.7-year co-hort study of a Japanese northern rural population[J].J Ath-eroscler Thromb,2011,18(2):89-98.
• [6]Neto JP,Lyra I M,Reis MG,et al.The association of infec-tion and clinical severity in sickle cell anaemia patients[J].Trans R Soc Trop Med Hyg,2011,105(3):121-126.
• [7]李秀钧,邬元红.糖尿病是一种炎症性疾病[J].中华内分泌代谢杂志,2003,19(4):251-253.