激素替代疗法对脑死亡后猪供体肺的影响Impact of hormone replacement therapy on lung donor with pigs after brain death
孙子瑞,方华,高峰,廖秋明,崔新征,杨鲲鹏,张清勇
摘要(Abstract)：
目的研究激素替代疗法对猪脑死亡后供体肺的保护作用。方法 20头瑞典健康家猪建立脑死亡模型,随机分为对照组和激素替代组(n=10)。采用ELISA方法检测脑死亡24 h后两组血清IL-1β水平;同时监测两组肺动脉灌流(Pulmonary Artery Flow,PAF)及动脉血气(pH、PCO2、PO2)等肺功能指标。结果脑死亡后24 h对照组IL-1β含量为(1.64±0.30)pg/mL显著高于激素替代组(1.14±0.31)pg/mL(P<0.05),对照组PAF(1.14±0.43)L/min明显低于激素替代组(3.78±0.71)L/min(P<0.05);同时动脉血气分析显示24 h后激素替代组pH、PO2、PCO2明显优于对照组(P<0.05)。结论 (1)在脑死亡24 h后激素替代疗法可以减少血清IL-1β的分泌,减轻肺损伤。(2)激素替代疗法对脑死亡后供体肺功能有一定的保护功能。
关键词(KeyWords)： 肺移植;脑死亡;肺供体;IL-1β
基金项目(Foundation):
作者(Author): 孙子瑞,方华,高峰,廖秋明,崔新征,杨鲲鹏,张清勇
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