婴儿单纯疱疹病毒性脑炎脑脊液检查、临床表现与病原学检测
崔喜红,罗淑颖,孟庆萍,崔瑞玲
摘要(Abstract):
目的分析单纯疱疹病毒性脑炎(HSVE)临床表现和脑脊液检查特点。方法回顾分析郑州儿童医院2007-03~2010-06收治的79例婴儿病毒性脑炎患者资料,对患儿的主要临床表现、脑脊液检查结果和病原学结果进行分析。结果经酶联免疫吸附试验和聚合酶链反应检测确诊为单纯疱疹病毒性脑炎24例,脑脊液白细胞及时增高和癫全身发作与HSV阳性相一致,所有HSVE患儿均有非特异系统症状,血性脑脊液等其他脑脊液检查结果均不能预示HSVE感染。结论婴儿HSV感染临床表现缺乏显著特点,脑脊液白细胞计数有助于本病的诊断,应尽早进行病原学检查。
关键词(KeyWords): 单纯疱疹病毒感染;脑炎;婴儿;PCR;ELISA
基金项目(Foundation):
作者(Author): 崔喜红,罗淑颖,孟庆萍,崔瑞玲
参考文献(References):
- [1]诸福棠,吴瑞萍,胡亚美.实用儿科学[M].北京:人民卫生出版社,2005:757.
- [2]Caviness AC.The prevalence of neonatal herpes si mplex virusinfection compared with serious bacterial illness in hospitalizedneonates[J].J Pediatr,2008,153(2):164-169.
- [3]De Tiege X.Li mits of early diagnosis of herpes si mplex en-cephalitis in children:a retrospective study of 38 cases[J].Clin Infect Dis,2003,36(10):1 335-1 339.
- [4]Caviness AC.The prevalence of neonatal herpes si mplex virusinfection compared with serious bacterial illness in hospitalizedneonates[J].J Pediatr,2008,153(2):164-169.
- [5]Ki mberlin DW,Whitley RJ.Neonatal herpes:what have welearned[J].Semin Pediatr Infect Dis,2005,16(1):7-16.
- [6]Ki mberlin DW.When should youinitiate acyclovir therapyin aneonate?[J].J Pediatr,2008,153(2):155-156.