殷彦,聂亚雄,朱云龙,尹剑

• 1:南华大学附属第一医院神经内科

摘要(Abstract)：

目的研究多烯磷脂酰胆碱注射液对局造性脑缺血大鼠的保护作用。方法若干只SD雄性大鼠,参照Longa法略加修改制作大脑中动脉闭塞模型,并进行神经功能评分,将神经功能评分为2分的18只脑缺血模型的大鼠随机分为3组,即模型组、早期药物干预组、晚期药物干预组,每组6只。药物干预组分别于术后2h、术后第3天开始连续3d腹腔注射多烯磷脂酰胆碱注射液80mg/(kg.d),各组未使用药物时分别给予等量生理盐水注射。造模后第6天清晨再次进行神经功能评分,并采血分离血清,用酶联免疫吸附测定法(ELISA)检测血清中NSE和TNF-α含量。结果用药前3组神经功能评分差异无统计学意义(P>0.05);血清NSE含量和TNF-α含量比较,早期药物干预组、晚期药物干预组与模型组间,差异有统计学意义(P<0.05),但早期药物干预组与晚期药物干预组比较,差异无统计学意义(P>0.05)。结论多烯磷脂酰胆碱注射液能通过减轻炎症反应,对缺血性脑损伤有一定的保护作用。

关键词(KeyWords)： 多烯磷脂酰胆碱注射液;脑缺血;肿瘤坏死因子;神经元特异性烯醇化酶

Abstract:

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基金项目(Foundation):

作者(Author): 殷彦,聂亚雄,朱云龙,尹剑

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