驱铜药治疗后肝豆状核变性神经系统症状恶化机制探讨
杨文明,李祥
摘要(Abstract)：
<正>肝豆状核变性(HLD)又称Wilson病,为一种遗传性铜代谢障碍所致的肝硬化和基底节为主的脑部变性疾病。研究证实,WD患者因ATP7B基因突变引起铜代谢障碍,使得游离的铜离子在肝、豆状核、角膜、肾脏等组织器官缓慢蓄
关键词(KeyWords)： 肝豆状核变性;驱铜剂;神经症状加重;病理机制
基金项目(Foundation): 国家自然科学基金(30973748);; 国家中医药管理局科研基金(06-07LP23)
作者(Author): 杨文明,李祥
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