尉娜,谭军,路坦

• 1:新乡医学院第三附属医院神经内科
• 2:新乡医学院第一附属医院骨外科

摘要(Abstract)：

目的探讨腺苷预处理对脑缺血再灌注损伤的保护作用和机制。方法制作大鼠脑缺血再灌注损伤模型。将大鼠随机分为3组:假手术组(F组)、缺血再灌注组(IR组)、腺苷预处理组(AP组),用Zeal Longa 5级评分法进行神经功能评分;免疫组织化学法检测脑组织内碱性成纤维细胞因子(basic fibroblast growth factor,bFGF)的表达。结果 (1)神经功能评分AP组各亚组均小于IR组各亚组(P均<0.05),但大于F组各亚组(P均<0.05);(2)F组bFGF阳性表达极弱,IR组和AP组在脑缺血再灌注后2 h开始出现bFGF弱阳性表达并逐渐增强,24 h达高峰,72 h略有下降,6 h2、4 h、72 h时AP组bF-GF阳性表达较IR组相应各亚组增强(P<0.05)。结论 (1)腺苷预处理能减轻大鼠局灶性脑缺血再灌注损伤所引起的神经功能缺损症状;(2)腺苷预处理能增强中枢神经系统内bFGF的分泌,进而起到保护脑组织的作用。

关键词(KeyWords)： 腺苷预处理;局灶性脑缺血再灌注;碱性成纤维细胞因子(bFGF)

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 尉娜,谭军,路坦

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